A novel microwave-assisted green synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones under solvent-free conditions

✍ Scribed by Kishor S. Jain; Jitender B. Bariwal; Manisha S. Phoujdar; Madhuri A. Nagras; Rakesh D. Amrutkar; Manoj K. Munde; Riyaj S. Tamboli; Samrat A. Khedkar; Rahul H. Khiste; Nikhil C. Vidyasagar; Vinit V. Dabholkar; M. K. Kathiravan

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 207 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.30

✦ Synopsis

Abstract

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A rapid microwave‐assisted green chemical synthesis of condensed 2‐substituted‐pyrimidin‐4(3__H__)‐ones 3, 4, and 5 involving the condensation of a variety of nitriles with o‐aminoesters of thiophene 2a, 2b, 2c, 2d, 2e, benzene 2f, dimethoxybenzene 2g and quinazolinone 2h in the presence of catalytic amount of HCl alone or with the Lewis acid AlCl~3~ under solvent‐free conditions, is described for the first time. This novel and clean one‐pot methodology, which is characterized by very short reaction times and easy workup procedures, can be exploited to generate a diverse library of condensed pyrimidine heterocycles. J. Heterocyclic Chem., (2009)