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Microwave-assisted three-component synthesis and in vitro antifungal evaluation of 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones

✍ Scribed by Jairo Quiroga; Carlos Cisneros; Braulio Insuasty; Rodrigo Abonía; Silvia Cruz; Manuel Nogueras; José Manuel de la Torre; Maximiliano Sortino; Susana Zacchino

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 126 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430208

No coin nor oath required. For personal study only.

✦ Synopsis

The reaction of 6-aminopyrimidin-4-ones 1 with benzaldehydes 2 and β-aminocrotononitrile 3 or benzoylacetonitrile 4 under microwave irradiation in dry media yields the 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidinones 5a-t. The structure of the synthesized compounds was determined on the basis of nmr measurements, especially by 1 H, 1 H-, 1 H, 13 C COSY, DEPT and NOESY experiments. In contrast with other pyrido-[2,3-d]pyrimidine derivatives, these compounds did not show any antifungal in vitro activity up to 250 µg/mL.

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