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Microwave-Assisted Three-Component Synthesis and in vitro Antifungal Evaluation of 6-Cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones.

✍ Scribed by Jairo Quiroga; Carlos Cisneros; Braulio Insuasty; Rodrigo Abonia; Silvia Cruz; Manuel Nogueras; Jose Manuel de la Torre; Maximiliano Sortino; Susana Zacchino


Publisher
John Wiley and Sons
Year
2006
Weight
20 KB
Volume
37
Category
Article
ISSN
0931-7597

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Microwave-assisted three-component synth
✍ Jairo Quiroga; Carlos Cisneros; Braulio Insuasty; Rodrigo AbonΓ­a; Silvia Cruz; M πŸ“‚ Article πŸ“… 2006 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 126 KB

The reaction of 6-aminopyrimidin-4-ones 1 with benzaldehydes 2 and Ξ²-aminocrotononitrile 3 or benzoylacetonitrile 4 under microwave irradiation in dry media yields the 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidinones 5a-t. The structure of the synthesized compounds was determined on the basis of nmr me