Microwave-assisted synthesis of sodium sulfonates precursors of sulfonyl chlorides and fluorides

✍ Scribed by Shakiru O. Alapafuja; Spyros P. Nikas; Vidyanand G. Shukla; Ioannis Papanastasiou; Alexandros Makriyannis

• Book ID: 104097033
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 243 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.09.167

✦ Synopsis

We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase.