## Abstract A novel strategy for a more efficient synthesis of difficult sequence‐containing peptides, the __S__‐acyl isopeptide method, was developed and successfully applied. A model pentapeptide Ac–Val–Val–Cys–Val–Val–NH~2~ was synthesized via its water‐soluble __S__‐acyl isopeptide using an __S
Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method
✍ Scribed by Hussein, Waleed M.; Liu, Tzu-Yu; Toth, Istvan; Skwarczynski, Mariusz
- Book ID
- 120013410
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 419 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1477-0520
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## Abstract A head‐to‐tail cyclization of a protected linear hexapeptide with a __C__‐terminal __O__‐acyl isopeptide proceeded to give a cyclic __O__‐acyl isopeptide without epimerization. The cyclic __O__‐acyl isopeptide possessed different secondary structures compared with the native cyclic pept
## Abstract ‘__O__‐Acyl isopeptide method’ is an efficient synthetic method for peptides. We designed ‘__O__‐acyl isodipeptide units’, Boc‐Ser/Thr(Fmoc‐Xaa)‐OH, as important building blocks to enable routine use of the __O__‐acyl isopeptide method. In the synthesis of an Aβ1–42 isopeptide using __O