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Microwave-assisted synthesis and antibacterial activity of derivatives of 3-[1-(4-fluorobenzyl)-1H-indol-3-yl]-5-(4-fluorobenzylthio)-4H-1,2,4-triazol-4-amine

✍ Scribed by Peng, Yong-Le; Liu, Xing-Li; Wang, Xiao-Hong; Zhao, Zhi-Gang

Book ID: 125443167
Publisher: Versita
Year: 2014
Tongue: English
Weight: 207 KB
Volume: 68
Category: Article
ISSN: 0366-6352
DOI: 10.2478/s11696-013-0461-2

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✦ Synopsis

Abstract

Herein, an excellent method for the synthesis of twelve novel Schiff base derivatives containing indole and triazole assisted by microwave irradiation is reported. Compared with the conventional method, the yields increased from 59–84 % to 85–96 % and the reaction time was reduced from 24–30 h to 4–8 min. Moreover, all series of the newly synthesized Schiff bases were evaluated for their antibacterial activity. The values of minimum inhibitory concentration (MIC) and IC50 indicated that many target compounds possessed excellent antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis.

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