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Microwave-assisted solvent-free organic reactions: Synthesis of β-lactams from 1,3-azadienes

✍ Scribed by Giorgio Martelli; Giuseppe Spunta; Mauro Panunzio


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
220 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


Ring-closure of 1,3-azadienes to 13-1actam rings is efficiently and quickly carried out under solvent-free conditions in an open-vessel microwave system. The synthesis of N-tert-butyldimethylsilyl azetidinones is reported.


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## Abstract magnified image Microwave‐assisted synthesis has been found to increase both reaction rates and yields __via__ more efficient heating compared with standard thermal conduction. Dry reaction of isatins with thiosemicarbazide and their thiosemicarbazone with secondary amine on acid—washe