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Microwave-Assisted Parallel Synthesis of a 14-Helical β-Peptide Library

✍ Scribed by Murray, Justin K.; Gellman, Samuel H.

Book ID
126853937
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
453 KB
Volume
8
Category
Article
ISSN
1520-4766

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A novel method for the synthesis of a library of substituted prolines utilizing microwave-assisted synthesis is described. The process involves rapid microwave irradiation of a-aminoesters and aldehydes to generate imines followed by the addition of a dipolarophile and subsequent irradiation to prod