Microwave-assisted multi-component synthesis of fused 3-aminoimidazoles

✍ Scribed by Sarah M. Ireland; Heather Tye; Mark Whittaker

• Book ID: 104253670
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 163 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00941-9

✦ Synopsis

A variety of fused 3-aminoimidazoles have been synthesised by a microwave assisted Ugi three-component coupling (3cc) reaction catalysed by scandium triflate in methanol as solvent. Yields of 33-93% have been achieved after just 10 min of microwave irradiation using a simple one-stage procedure. The methodology described is suitable for the rapid and efficient synthesis of a range of fused heterocycles of pharmacological interest.