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Microwave-assisted “green” synthesis of 2-alkyl/arylbenzothiazoles in one pot: A facile approach to anti-tumor drugs

✍ Scribed by Sukanta Kamila; Benjamin Koh; Edward R. Biehl

Book ID
102338225
Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
220 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image

A series of new 2‐alkyl/arylbenzothiazoles has been synthesized on the basis of the potent and selective in vitro anti‐tumor properties of 2‐(3,4‐diethoxyphenyl)‐5‐fluorobenzothiazole. The synthesis of benzothiazole analogs was achieved via microwave irradiation of a 1:1 mixture of o‐aminothiophenol and alkyl/aryl acylacetonitriles at temperature of 200°C for 10 min. The yields are very good to excellent. All the products were characterized by ^1^H nmr, ^13^C nmr and elemental analysis.

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