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Green chemistry approach to the synthesis of 2-amino-4-aryl-6-ferrocenyl-pyridine derivatives by a one-pot reaction in aqueous medium
β Scribed by Qiya Zhuang; Runhong Jia; Shujiang Tu; Junyong Zhang; Bo Jiang; Yan Zhang; Changsheng Yao
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 410 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Abstract
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A clean and facile green chemistry method for the synthesis of a series of 2βaminoβ4βarylβ6βferrocenylpyridine derivatives was afforded. The products were synthesized via the oneβpot reaction of aromatic aldehyde, malononitrile or ethyl cyanoacetate, acetylferrocene and ammonium acetate in aqueous medium under microwave irradiation and conventional heating conditions without catalyst. This method had several advantages such as higher yield, lower cost, reduced environmental impact, and convenient procedure.
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