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Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase

✍ Scribed by Estelle Gallienne; Giulio G. Muccioli; Didier M. Lambert; Michael Shipman

Book ID: 104095779
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 162 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.08.100

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✦ Synopsis

a b s t r a c t Monothiohydantoin 3a is made in seven steps from 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC 50 = 23.4 ± 1.1 lM). The key step in the sequence involves a microwaveassisted four-component reaction that makes the 5,5 0 -disubstituted hydantoin nucleus by the sequential formation of two C-C and two C-N bonds.

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