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A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

โœ Scribed by Benson, N; Metelkin, E; Demin, O; Li, G L; Nichols, D; van der Graaf, P H


Book ID
121504973
Publisher
Wiley (John Wiley & Sons)
Year
2014
Tongue
English
Weight
611 KB
Volume
3
Category
Article
ISSN
2163-8306

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Microwave-assisted four-component reacti
โœ Estelle Gallienne; Giulio G. Muccioli; Didier M. Lambert; Michael Shipman ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 162 KB

a b s t r a c t Monothiohydantoin 3a is made in seven steps from 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC 50 = 23.4 ยฑ 1.1 lM). The key step in the sequence involves a microwaveassisted four-component reaction that makes the 5,5 0 -disubstituted hydantoin nu