Microwave-assisted four-component reacti
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Estelle Gallienne; Giulio G. Muccioli; Didier M. Lambert; Michael Shipman
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Article
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2008
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Elsevier Science
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French
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a b s t r a c t Monothiohydantoin 3a is made in seven steps from 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC 50 = 23.4 ยฑ 1.1 lM). The key step in the sequence involves a microwaveassisted four-component reaction that makes the 5,5 0 -disubstituted hydantoin nu