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Microwave accelerated three-component fluoroalkylations: expeditious routes to fluoropharmaceuticals and PET ligands

✍ Scribed by Michael Placzek; Paul LaBeaume; Luke Harris; Patrick Ng; Mathew Daniels; Amy Kallmerten; Graham B. Jones

Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 496 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.11.056

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✦ Synopsis

One-pot three-component coupling methods have been developed to allow in situ preparation of fluoroalkylated arenes and hydrocarbon chain analogs. The methods, which are accelerated under microwave irradiation gives access to x-fluorinated alkyl, alkenyl, and alkynyl substituted arenes from readily available precursors. The methods involve late stage introduction of the fluorine and are well suited to application in the synthesis of 18 F labeled PET imaging agents.

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