Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the prepa
ChemInform Abstract: Microwave-Accelerated Fluorodenitrations and Nitrodehalogenations: Expeditious Routes to Labeled PET Ligands and Fluoropharmaceuticals.
β Scribed by Graham B. Jones; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 46 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
One-pot three-component coupling methods have been developed to allow in situ preparation of fluoroalkylated arenes and hydrocarbon chain analogs. The methods, which are accelerated under microwave irradiation gives access to x-fluorinated alkyl, alkenyl, and alkynyl substituted arenes from readily