Microwave-Accelerated O -Alkylation of Carboxylic Acids with O -Alkylisoureas
β Scribed by Crosignani, Stefano; White, Peter D.; Linclau, Bruno
- Book ID
- 121848455
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 58 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
The reaction of O-alkylisoureas with sulphinic acids was found to produce the corresponding sulphones and sulphinates, the latter being predominantly formed. The sulphinate to sulphone ratio is strongly influenced by the kind of alkyl groups in the 0-alkylisourea and appeared to be also dependent on
Kinetic investigations on the reaction of N,N'-dicyclohexyl-O-(1-methylheptyl)isourea with acetic acid are described. The conversion proceeds partly through the intermediacy of a methylheptylcarbenium ion. However, in dilute solution an S N 2 mechanism prevails. The results are discussed in terms of