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Microsomal P450-Catalyzed N-Dealkylation of N,N-Dialkylanilines: Evidence for a Cα−H Abstraction Mechanism

✍ Scribed by Bhakta, Mehul N.; Wimalasena, Kandatege

Book ID
111887232
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
36 KB
Volume
124
Category
Article
ISSN
0002-7863

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## Abstract To determine the feasibility of using NMR to study the inactivation of cytochromes P‐450 by dichloroacetamide‐containing mechanism‐based inactivators, ^13^C, ^15^N‐enriched compounds were synthesized, modeling adducts between the nucleophilic side‐chains of cysteine, lysine, serine (thr