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Microsomal lipid peroxidation: Mechanisms of initiation: The role of iron and iron chelators

โœ Scribed by Fulvio Ursini; Matilde Maiorino; Paul Hochstein; Lars Ernster

Book ID
113384633
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
417 KB
Volume
6
Category
Article
ISSN
0891-5849

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The role of iron in the initiation of li
The role of iron in the initiation of lipid peroxidation
โœ Giorgio Minotti; Steven D. Aust ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 952 KB

Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe 3รท and Fe aรท, perhaps with oxygen to form a Fe3+-dioxygen-Fe 2รท complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, axe de