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Microsatellite mutation rates in cancer cell lines deficient or proficient in mismatch repair

✍ Scribed by Hanford, Marsha G; Rushton, Benjamin C; Gowen, Lori C; Farber, Rosann A


Book ID
110061277
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
325 KB
Volume
16
Category
Article
ISSN
0950-9232

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Microsatellite instability (MSI) caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome but is also found in about 15% of all sporadic tumors. Most affected microsatellites reside in untranslated inter