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Microsatellite instability in precancerous lesions and adenocarcinomas of the stomach

✍ Scribed by Shuho Semba; Hiroshi Yokozaki; Soichiro Yamamoto; Wataru Yasui; Eiichi Tahara

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
749 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

It is generally known that replication errors (RERs) at microsatellite loci detected in human malignancies reflect a genetic instability that is caused by abnormalities of DNA mismatch repair system and underlie human carcinogenesis. The authors analyzed RERs in precancerous lesions and adenocarcinomas of the stomach to learn when genetic instability occurs in stomach carcinogenesis. In addition, the authors examined genetic alterations of the p53 and adenoniatous polyposis coli (APC) genes to investigate the correlation between genetic instability and genetic alterations in these tumor suppressor genes.

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