Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways

The common 18-base pair deletion at codo

The common 18-base pair deletion at codons 418-423 of the E-cadherin gene in differentiated-type adenocarcinomas and intramucosal precancerous lesions of the stomach with the features of gastric foveolar epithelium

✍ Endoh, Yasushi; Tamura, Gen; Watanabe, Hidenobu; Ajioka, Yoichi; Motoyama, Teiic 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB 👁 1 views

Alterations of the E (epithelial)-cadherin gene are often involved in undifferentiated-type carcinomas of the stomach, but not in the differentiated type. Recently, it was recognized that certain differentiated-type carcinomas possess the features of gastric foveolar epithelium. Such carcinomas are