Microsatellite Instability in Gastric Intestinal Metaplasia in Patients with and without Gastric Cancer
β Scribed by Wai K. Leung; Jae J. Kim; Jong G. Kim; David Y. Graham; Antonia R. Sepulveda
- Book ID
- 117022364
- Publisher
- American Society for Investigative Pathology
- Year
- 2000
- Tongue
- English
- Weight
- 686 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0002-9440
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## Abstract Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a precancerous lesion of the stomach, our study examines the presence of gene promoter hypermethylation in IM of p
To better elucidate the role of genetic instability in the development of gastric cancer, microsatellite alterations were examined in a total of 30 gastric cancers that developed in 14 Japanese patients with multiple gastric cancers, which are considered to have possibly occurred under the same gene