Microsatellite Instability in Early-onset Breast Cancer
✍ Scribed by Erdener Özer; Erdinc Yuksel; Sefa Kizildag; Ogun Sercan; Emek Özen; Tulay Canda; Meral Sakizli
- Book ID
- 111731590
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 102 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0344-0338
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Human breast-cancer specimens from 100 patients were analyzed for microsatellite instability (referred to as replication error; RER) at I 2 genomic loci on 7 chromosomes, and results were correlated with clinicopathologic characteristics. In 42 of I00 breast-cancer patients, we investigated whether
Sporadic cancers and familial breast cancers are characterized by an increase in genetic instability. Little is known about whether mismatch repair defects accompany this genetic instability. We investigated invasive and/or in situ breast cancers from 30 women with deleterious BRCA1/2 mutations and