Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (/L)-/a and p map to this region, and the p gene is deregulated in some AMLs. Using pulsed-field gel electrophoresis techniques,
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Microsatellite analysis of recurrent chromosome 2 deletions in acute myeloid leukaemia induced by radiation in FI hybrid mice
โ Scribed by D. J. Clark; E.I. M. Meijne; S. D. Bouffler; R. Huiskamp; C. J. Skidmore; R. Cox; A.R. J. Silver
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 814 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1045-2257
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Chromosome 2 (chr 2) deletions are recurrent abnormalities in acute myeloid leukemia (AML) induced by ionizing radiation in the mouse. The localization of deletion sites has proven extremely useful in providing information on the molecular mechanisms of leukemogenesis. The models available for the s