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MicroRNAs that silence tau expression are dysregulated in Alzheimer's disease

✍ Scribed by Santa-Maria, Ismael; Alaniz, Maria Eugenia; Renwick, Neil; Tuschl, Thomas; Clark, Lorraine; Crary, John

Book ID
123434624
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
50 KB
Volume
9
Category
Article
ISSN
1552-5260

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## Abstract The degradation of aberrantly phosphorylated tau in neurons plays an important role in the pathogenesis of Alzheimer's disease (AD). hHrd1 is a newly identified ubiquitin ligase involved in the endoplasmic reticulum (ER)‐associated protein degradation. The expression and function of hHr