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MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer

✍ Scribed by Jun Hao; Shuyu Zhang; Yingqi Zhou; Cong Liu; Xiangui Hu; Chenghao Shao

Book ID: 116301478
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 620 KB
Volume: 406
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2011.02.086

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DPC4/SMAD4 is a candidate tumor suppressor gene with a strikingly high frequency of gene alterations in pancreatic cancer that suggests a discrete role for DPC4 in these tumors. DPC4 tumor-suppressive function has been implicated to mediate the transforming growth factor-b (TGFb)±suppressive pathway