Micronuclei and gene mutations in transgenic Big Blue® mouse and rat fibroblasts after exposure to the epoxide metabolites of 1,3-butadiene

Mutational specificity: Assessment of 1,

Mutational specificity: Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacl transgenic mice (Big Blue®): A review of mutational spectrum and LACL mutant frequency after a 5-day 625 PPM 1,3-butadiene exposure

✍ Leslie Recio; Kathy G. Meyer; Linda J. Pluta; Owen R. Moss; Christopher J. Saran 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 547 KB

Carolina 1,3-Butadiene (BD) is a carcinogen that is bioactivated to at least two genotoxic metabolites. In the present article, we review briefly our previous studies on the in vivo mutagenicity and mutational spectra of BD in bone marrow and extend these studies to examine the effect of exposure ti