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Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

✍ Scribed by Jae K Ryu; Atsushi Nagai; Jean Kim; Min C Lee; James G McLarnon; Seung U Kim


Book ID
117688492
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
599 KB
Volume
12
Category
Article
ISSN
0969-9961

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Mitochondria play a critical role in cell death by releasing apoptogenic factors, such as cytochrome c and apoptosis-inducing factor (AIF), from the intermembrane space into the cytoplasm. Because mitochondrial dysfunction has been shown to be involved in several neurodegenerative diseases, mitochon