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Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro

✍ Scribed by Anthony Lyons; Aileen M. Lynch; Eric J. Downer; Riona Hanley; Joan B. O’Sullivan; Andrew Smith; Marina A. Lynch


Book ID
111183571
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
549 KB
Volume
110
Category
Article
ISSN
0022-3042

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## Abstract We have shown that prothrombin kringle‐2 (pKr‐2), a domain of human prothrombin distinct from thrombin could activate cultured rat brain microglia in vitro. However, little is known whether pKr‐2‐induced microglial activation could cause neurotoxicity on dopaminergic (DA) neurons in viv