𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Microglia in degenerative neurological disease

✍ Scribed by Dr. Patrick L. McGeer; Toshio Kawamata; Douglas G. Walker; Haruhiko Akiyama; Ikuo Tooyama; Edith G. McGeer

Book ID
102845818
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
994 KB
Volume
7
Category
Article
ISSN
0894-1491

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✦ Synopsis

Microglia express many leukocyte surface antigens which are upregulated in such chronic degenerative neurological diseases as Alzheimer's disease (AD) and amyotrophic lateral sclerosis !ALS). These surface antigens include leukocyte common antigen, immiinoglobulin Fc receptors, MHC class I and class I1 glycoproteins, p2-integrins, and the vitronectin receptor. Ligands for these receptors are also found. They include immunoglobulins, complement proteins of the classical pathway, 'I' lymphocytes Address reprint requests t o Dr Patrick L ILlcGeer. 2256 Westhrook Mall, UniversityofB (:, Vnnrouver. H.C. V6T 1WS. Canada.

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