✦ LIBER ✦

Microglia in HIV-associated neurological diseases

✍ Scribed by Jonathan D. Glass; Steve L. Wesselingh

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 190 KB
Volume: 54
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.1124

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human immunodeficiency virus type‐1 (HIV‐1) is a neurotropic virus linked to a variety of progressive neurologic disorders. This review describes our current understanding of how HIV‐1 enters the nervous system and interacts with neuronal and non‐neuronal cells to initiate and sustain neurologic dysfunction. The overwhelming majority of cells infected with HIV‐1 in the nervous system are microglia/macrophages. Microglial/macrophage infection leads to immune dysregulation as well as production and release of cytotoxic molecules. Interaction of these infected cells with astrocytes may accelerate neurotoxic mechanisms. A hypothetical scenario for how HIV‐1 infection leads to neurologic disease is presented. Microsc. Res. Tech. 54:95–105, 2001. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Neuromuscular diseases associated with H

Neuromuscular diseases associated with HIV-1 infection

✍ Jessica Robinson-Papp; David M. Simpson 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB

Microglia in health and disease

✍ Seung U. Kim; Jean de Vellis 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB

## Abstract Microglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell

Therapeutic plasma exchange in neurologi

Therapeutic plasma exchange in neurological diseases

✍ Peter C. Dau; Tommie Wolff 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB

HIV-associated multicentric Castleman's

HIV-associated multicentric Castleman's disease

✍ Justin Stebbing; Liron Pantanowitz; Farshid Dayyani; Ryan J. Sullivan; Mark Bowe 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB 👁 1 views

## Abstract Multicentric Castleman's disease (MCD), a relatively rare lymphoproliferative disorder that presents with heterogenous symptoms including fevers, anemia, and multifocal lymphadenopathy, is today most commonly observed in individuals infected with human immunodeficiency virus type‐1 (HIV

Effects of anti–glutamic acid decarboxyl

Effects of anti–glutamic acid decarboxylase antibodies associated with neurological diseases

✍ Mario-Ubaldo Manto; Marie-Aline Laute; Michèle Aguera; Véronique Rogemond; Massi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

Association of human T-lymphotropic viru

Association of human T-lymphotropic viruses in chronic neurological disease

✍ Elaine DeFreitas; Takahiko Saida; Yuzo Iwasaki; Hilary Koprowski 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 2 views

We recently published a report describing the association of a human retrovirus related to human T-lymphotropic virus type I (HTLV-I) in patients with multiple sclerosis (MS) in Sweden and southern Florida E73. A meeting was held at The Wistar Institute in Philadelphia on July 29-30, 1986, to update