Microencapsulated Ciliary Neurotrophic Factor: Physical Properties and Biological Activities
β Scribed by Dusica Maysinger; Kerstin Krieglstein; Jelena Filipovic-Grcic; Michael Sendtner; Klaus Unsicker; Peter Richardson
- Book ID
- 115606316
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 521 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0014-4886
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Four monoclonal antibodies to a purified ciliary neurotrophic factor have been produced by a combination of in vivo and in vitro immunization of mouse lymphocytes. Three of the antibodies-3D12, an 1gA subtype, and 5G9 and 2Bl1, both IgM subtypesbound to the single band on immunoblots of the purified
## Abstract Studies have shown that cytokines released following CNS injury can affect the supportive or cytotoxic functions of microglia. Interleukinβ6 (ILβ6)βfamily cytokines are among the injury factors released. To understand how microglia respond to ILβ6 family cytokines, we examined the effec