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Monoclonal antibody that inhibits biological activity of a mammalian ciliary neurotrophic factor

✍ Scribed by D. Watters; D. Belford; C. Hill; Dr. I. Hendry

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 495 KB
Volume: 22
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490220108

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✦ Synopsis

Four monoclonal antibodies to a purified ciliary neurotrophic factor have been produced by a combination of in vivo and in vitro immunization of mouse lymphocytes. Three of the antibodies-3D12, an 1gA subtype, and 5G9 and 2Bl1, both IgM subtypesbound to the single band on immunoblots of the purified factor. Of the four clones only one, 3D12, produced antibodies able to inhibit the biological activity of the neurotrophic factor in promoting the survival of ciliary neurones in dissociated culture.

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