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Microdialysis Study of the Neuropharmacokinetics of Phenytoin in Rat Hippocampus and Frontal Cortex

โœ Scribed by M. C. Walker; M. S. Alavijeh; S. D. Shorvon; P. N. Patsalos

Book ID
114748038
Publisher
Wiley (Blackwell Publishing)
Year
1996
Tongue
English
Weight
597 KB
Volume
37
Category
Article
ISSN
0013-9580

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A microdialysis study of glycinamide, gl
A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug
โœ Mary H. Doheny; Shigeru Nagaki; Philip N. Patsalos ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 673 KB

Milacemide is a glycinamide derivative which readily enters the brain and is metabolised to glycine. As its mechanism of action as an anticonvulsant drug is unknown we used the technique of microdialysis to study the temporal inter-relationship of glycinamide, glycine and other amino acid neurotrans