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Vigabatrin extracellular pharmacokinetics and concurrent γ-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis

✍ Scribed by Xin Tong; Neville Ratnaraj; Philip N. Patsalos

Book ID
109111017
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
564 KB
Volume
50
Category
Article
ISSN
0013-9580

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✍ Mary H. Doheny; Shigeru Nagaki; Philip N. Patsalos 📂 Article 📅 1996 🏛 Springer-Verlag 🌐 English ⚖ 673 KB

Milacemide is a glycinamide derivative which readily enters the brain and is metabolised to glycine. As its mechanism of action as an anticonvulsant drug is unknown we used the technique of microdialysis to study the temporal inter-relationship of glycinamide, glycine and other amino acid neurotrans