The effects of acetaminophen on the metabolism of the isolated perfused rat liver were investigated. The following results were obtained: (1) Acetaminophen increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). (2) Oxygen uptake, gluconeogenesis from either pyruvate or
Microcalorimetric investigations of the metabolism of an isolated perfused rat liver
โ Scribed by F. Baisch
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 646 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-6031
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Irinotecan (CPT-11) is a semisynthetic derivative of camptothecine that has proved activity in the treatment of colorectal carcinoma. The metabolites identiยฎed in humans include SN-38, SN-38 glucuronide, and several CYP3A-derived metabolites. We have studied the hepatic extraction, metabolism, and b
## Abstract The effects of zymosan on transport, distribution, and metabolism of octanoate in the perfused rat liver were investigated using the multipleโindicator dilution technique. Livers were perfused with 300 ยตM octanoate in the absence or in the presence of 100 ยตg/mL zymosan. Tracer amounts o
Hepatic metabolism of salicylic acid was studied using a single-pass liver perfusion technique. Livers obtained from male, Sprague-Dawley rats (200-300 g) were perfused with Krebs-Henseleit bicarbonate buffer containing the drug (50-100 micrograms/mL) and glycine (0.5 or 5 mM) or glucose (5.5 mM) or