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Microcalorimetric investigations of pharmaceutical complexes II. Drug-albumin interactions

✍ Scribed by Masaki Otagiri; Greg E. Hardee; John H. Perrin

Book ID
118316664
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
228 KB
Volume
27
Category
Article
ISSN
0006-2952

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πŸ“œ SIMILAR VOLUMES

Microcalorimetric investigations of drug
Microcalorimetric investigations of drug–albumin interactions
✍ G. H. Hardee; J. S. Fleitman; M. Otagiri; J. H. Perrin πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 352 KB

Flow microcalorimetry was used to estimate primary binding constants for drugalbumin interactions. Measurements of heat of reaction at two temperatures illustrated the danger of extrapolation for pharmacokinetic purposes of measurements made at temperatures other than 37". The method could be used t