𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Microcalorimetric investigations of drug–albumin interactions

✍ Scribed by G. H. Hardee; J. S. Fleitman; M. Otagiri; J. H. Perrin

Book ID
101701977
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
352 KB
Volume
5
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Flow microcalorimetry was used to estimate primary binding constants for drugalbumin interactions. Measurements of heat of reaction at two temperatures illustrated the danger of extrapolation for pharmacokinetic purposes of measurements made at temperatures other than 37". The method could be used to predict competition between two drugs for a single binding site. Major advantages over spectroscopic techniques included direct determinations of thermodynamic parameters, and the use of physiological concentrations of albumin,

📜 SIMILAR VOLUMES

Drug-albumin interactions using spin lab
Drug-albumin interactions using spin labeling
✍ J. Blanchard; T. N. Tozer; D. L. Sorby; L. Dallas Tuck 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

sodium carbonate mixture could be predicted to be the most stable blend after 1 day of testing. The prediction was clearly confirmed by results of a classical stability study requiring up to 6 months of storage at 50".