Microcalorimetric assessment of gyrase-inhibitors
โ Scribed by F. Allerberger; M.P. Dierich
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 835 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0040-6031
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Nalidixic acid inhibits the expression of those cysteine genes which are regulated by the cysB product, it has no affect, however, on the constitutively expressed eysE gene. The expression of cysteine genes in a strain carrying a mutation in the nalA locus is resistant to this drug. Novobiocin affec
The number and strength of the acid sites of a variety of NaHZSM-5 zeolites were measured as a function of the exchange level using NH, adsorption monitored by microcalorimetry. While the number of acid sites increased quasi linearly with the exchange level, the acid strength remained almost consta
The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory pot
## Abstract A series of 4โquinazoloneโ5โcarboxylic acids were designed as bacterial DNA gyrase inhibitors. The syntheses of the target compounds were accomplished by reacting 3โaminophthalimide with aroyl chlorides followed by rearrangement of the resulting 3โacylaminophthalimides under basic condi
AbstractรThe synthesis and biological proยฎle in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3 H of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxycarbamate bioisostere leads to analogues w