✍ Scribed by M. Iqbal Choudhary; Syed Ghulam Musharraf; Mahmud Tareq Hassan Khan; Doaa Abdelrahman; Massod Parvez; Farzana Shaheen; Atta-ur-Rahman
No coin nor oath required. For personal study only.
The microbial transformation of (+)‐isolongifolen‐4‐one (4) by a number of fungi by means of a standard two‐stage fermentation technique afforded (7__R__)‐12‐hydroxyisolongifolen‐4‐one (5), (7__S__)‐13‐hydroxyisolongifolen‐4‐one (6), (11__R__)‐11‐hydroxyisolongifolen‐4‐one (7), (10__R__)‐10‐hydroxyisolongifolen‐4‐one (8), and (9__R__)‐9‐hydroxyisolongifolen‐4‐one (9) (Scheme). All five metabolites were found to be new, and metabolites 6 and 9 showed potent tyrosinase inhibitory activity (Table 1). The metabolites and their derivatives were characterized on the basis of spectroscopic and single‐crystal X‐ray‐diffraction techniques.
📜 SIMILAR VOLUMES
## Abstract The microbial transformation of a sesquiterpene lactone, l‐α‐santonin was carried out by __Streptomyces roseochromogenes__ NRRL‐B‐1233. The product obtained from l‐α‐sanatonin was purified using silica gel column chromatography with 1% acetone‐benzene as the eluant. The molecular weight