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Studies on microbial transformations XVIII. Microbiological transformation of l-α-santonin

✍ Scribed by Dr. M. Iida; Y. Hatori; K. Yamakawa; H. Iizuka

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
253 KB
Volume
21
Category
Article
ISSN
0233-111X

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✦ Synopsis

Abstract

The microbial transformation of a sesquiterpene lactone, l‐α‐santonin was carried out by Streptomyces roseochromogenes NRRL‐B‐1233. The product obtained from l‐α‐sanatonin was purified using silica gel column chromatography with 1% acetone‐benzene as the eluant. The molecular weight of the product was 248, estimated by mass spectroanalysis. The product was assignad the chemical structure of 1,2‐dihydro‐l‐α‐santonin on the bases of ^1^H and ^13^C‐NMR and mass spectro‐analyses. Similar products were also obtained from other actinomycetes. The conversion of l‐α‐santonin to 1,2‐dihydro‐l‐α‐santonin was 28% for Streptomyces roseochromogenes NRRL‐B‐1233, 14% for S. roseochromogenes ATCC 13400, 30.9% for S. aureofaciens KCC‐S‐0008, and 43.0% for S. aureofaciens KCC‐S‐0624, respectively.

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