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Microbial transformation of 14-deoxy-11, 12-didehydroandrographolide and 14-deoxyandrographolide and inhibitory effects on nitric oxide production of the transformation products

✍ Scribed by Li-Xia Chen; Yu-Lei Zhuang; Lan Shen; En-Long Ma; Hua-Jie Zhu; Feng Zhao; Feng Qiu


Book ID
113804883
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
590 KB
Volume
72
Category
Article
ISSN
1381-1177

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14-deoxyandrographolide (DA) and 14-deoxy-11,12-didehydroandrographolide (DDA) are two diterpenoids isolated from A. paniculata, a popular folk medicine used as an antihypertensive drug in Malaysia. We have previously reported that DDA exhibited a greater hypotensive effect in anaesthetized rats and