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Microbial production of 1α-hydroxyvitamin D 3 from vitamin D 3

✍ Scribed by Ahmed, Safwat A.; Mesbah, Mostafa K.; Youssef, Diaa T.; Khalifa, Sherief I.

Book ID
127336596
Publisher
Taylor and Francis Group
Year
2014
Tongue
English
Weight
119 KB
Volume
28
Category
Article
ISSN
1478-6419

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✍ Joji Sasaki; Akiko Miyazaki; Mika Saito; Takashi Adachi; Kazutoshi Mizoue; Kazun 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 580 KB

To enzymatically synthesize active metabolites of vitamin D3, we screened about 500 bacterial strains and 450 fungal strains, of which 12 strains were able to convert vitamin D 3 to lc~,25-dihydroxyvitamin D3 [lc~,25(OH)2.D3] via 25-hyroxyvitamin D3 [25(OH)Da]. The conversion activity was only detec