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Microbial oxidation of the antimalarial drug arteether

✍ Scribed by Yulin Hu; Herman Ziffer; Guiying Li; Herman J.C. Yeh

Book ID
103479346
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
425 KB
Volume
20
Category
Article
ISSN
0045-2068

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Synthesis of 11-[3H]-arteether, an exper
Synthesis of 11-[3H]-arteether, an experimental antimalarial drug
✍ Yu-Ming Pu; Herman Ziffer πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 262 KB

## Abstract The triphenylphosphine hydrobromide‐catalyzed addition of a proton from ethanol to anhydrodihydroartemisinin (5) has been employed for the synthesis of 2 and 4 Use of 1.5 equivalents of EtO^2^H or EtO^3^H yielded 11‐[~3~H]‐β‐arteether as the major product.