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Microbial metabolism of 2-arylpropionic acids: Chiral inversion of ibuprofen and 2-phenylpropionic acid

โœ Scribed by Dr. Andrew J. Hutt; Azam Kooloobandi; Geoffrey W. Hanlon

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
704 KB
Volume
5
Category
Article
ISSN
0899-0042

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๐Ÿ“œ SIMILAR VOLUMES

A mechanistic investigation of the micro
A mechanistic investigation of the microbial chiral inversion of 2-phenylpropionic acid by Verticillium lecanii
โœ M. J. Thomason; W. Rhys-Williams; Y.-F. Hung; J. A. Baker; G. W. Hanlon; A. W. L ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 182 KB

Previous investigations have described the development of nongrowing suspensions of Verticillium lecanii as a microbial model of the mammalian chiral inversion of the 2-arylpropionic acids (2-APAs). Mechanistic studies in mammals have shown that inversion involves loss of the โฃ-methine proton but re

Extent of chiral inversion of the 2-aryl
Extent of chiral inversion of the 2-arylpropionic acids by Cordyceps militaris
โœ W. Rhys-Williams; M. J. Thomason; Y.-F. Hung; G. W. Hanlon; A. W. Lloyd ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 81 KB

The fungus Cordyceps militaris has been previously shown to be capable of inverting the chirality of 2-phenylpropionic acid from its (R)-enantiomer to its (S)antipode. The structure of this compound is similar to the 2-arylpropionic acid nonsteroidal anti-inflammatory drugs, which have also been rep