Microbial Degradation of Cephalosporin C
β Scribed by DEMAIN, ARNOLD L.; WALTON, ROBERT B.; NEWKIRK, JOANNE F.; MILLER, IAN M.
- Book ID
- 109630534
- Publisher
- Nature Publishing Group
- Year
- 1963
- Tongue
- English
- Weight
- 236 KB
- Volume
- 199
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/199909a0
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π SIMILAR VOLUMES
## Abstract The degradation of cefaclor (1), an oral cephalosporin antibiotic, was studied at 37Β° in a neutral aqueous medium by HPLC and ^1^HβNMR. Under these conditions, 1 underwent intramolecular aminolysis by the 7βsideβchain NH~2~ group on the Ξ²βlactam moiety to give a piperazineβ2,5βdione. Th
Acetyl Coeaxymc A 4 -CeplMqcfia c Intact cell experiment8 have demonstrated that %,3!,-"C-valine (5a) gave 4-LaC-cepha108Porin C (6a).\* whilst 22.32-\*'C-valine (5b) gave 3-methylene-"C-Cephaloeporin C (6b).' 58)AI "CH,; B -"CW,