The synthesis of 2-ketopiperazine acetic
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Matthew M Abelman; Karl J Fisher; Edward M Doerffler; Paul J Edwards
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Article
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2003
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Elsevier Science
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French
⚖ 118 KB
The reaction of substituted ethylenediamines with various fumarates, maleates, and maleimides to form substituted ketopiperazine acetic acid esters and amides was investigated. This method affords a straightforward, high yield approach to a variety of potential peptidomimetics and can yield surprisi