The synthesis of 2-ketopiperazine acetic acid esters and amides from ethylenediamines with maleates and maleimides

✍ Scribed by Matthew M Abelman; Karl J Fisher; Edward M Doerffler; Paul J Edwards

• Book ID: 104253042
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 118 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00103-5

✦ Synopsis

The reaction of substituted ethylenediamines with various fumarates, maleates, and maleimides to form substituted ketopiperazine acetic acid esters and amides was investigated. This method affords a straightforward, high yield approach to a variety of potential peptidomimetics and can yield surprising results with regard to regio-and stereoselectivity.