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Japanese regulatory approaches to clarify the significance of positive results in in vitro mammalian cell genotoxicity assays" Joe Contrera, US Food and Drug Administration, CDER, Washington DC "Examples from current experience with in vitro genotoxins, with discussion of how transgenic mouse tumori
Fanconi anemia (FA) is a chromosome instability syndrome. Chromosomal aberrations (CA) are mainly of the chromatid-type suggesting that a deficiency in post-replicative repair may be involved. Our objective was to study whether inhibition of deoxyribonucleotide (dNTP) synthesis during the G2 phase b
Mutations in BRCA1 are responsible for most of the hereditary ovarian and breast cancers. The ability of BRCA1 to transactivate the p21 promoter can be inactivated by mutation of the C-terminal conserved BRCT domains. To explore the mechanisms of this BRCA1 function, the BRCT domains were found to
The phytoestrogen coumestrol (COUM) has been shown to induce DNA strand breaks, micronuclei and chromosomal aberrations in vitro but was negative in the Salmonella Ames assay. To further investigate the mechanism of COUM-induced chromosomal aberrations and micronuclei (MN), we treated cultured human