𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Program 2000 Environmental Mutagen Society Annual Meeting April 8–April 13, 2000 New Orleans, LA. Jim Tucker, Program Chair

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
30 KB
Volume
35
Category
Article
ISSN
0893-6692

No coin nor oath required. For personal study only.

✦ Synopsis

Japanese regulatory approaches to clarify the significance of positive results in in vitro mammalian cell genotoxicity assays" Joe Contrera, US Food and Drug Administration, CDER, Washington DC "Examples from current experience with in vitro genotoxins, with discussion of how transgenic mouse tumorigenicity models are considered in clarifying genotoxicity issues"

📜 SIMILAR VOLUMES

Program 2000 Environmental Mutagen Socie
Program 2000 Environmental Mutagen Society Annual Meeting April 8–April 13, 2000 New Orleans, LA. Jim Tucker, Program Chair
📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB

Fanconi anemia (FA) is a chromosome instability syndrome. Chromosomal aberrations (CA) are mainly of the chromatid-type suggesting that a deficiency in post-replicative repair may be involved. Our objective was to study whether inhibition of deoxyribonucleotide (dNTP) synthesis during the G2 phase b

Program 2000 Environmental Mutagen Socie
Program 2000 Environmental Mutagen Society Annual Meeting April 8–April 13, 2000 New Orleans, LA. Jim Tucker, Program Chair
📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB

Mutations in BRCA1 are responsible for most of the hereditary ovarian and breast cancers. The ability of BRCA1 to transactivate the p21 promoter can be inactivated by mutation of the C-terminal conserved BRCT domains. To explore the mechanisms of this BRCA1 function, the BRCT domains were found to

Program 2000 Environmental Mutagen Socie
Program 2000 Environmental Mutagen Society Annual Meeting April 8–April 13, 2000 New Orleans, LA. Jim Tucker, Program Chair
📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

The phytoestrogen coumestrol (COUM) has been shown to induce DNA strand breaks, micronuclei and chromosomal aberrations in vitro but was negative in the Salmonella Ames assay. To further investigate the mechanism of COUM-induced chromosomal aberrations and micronuclei (MN), we treated cultured human

Program 2000 Environmental Mutagen Socie
Program 2000 Environmental Mutagen Society Annual Meeting April 8–April 13, 2000 New Orleans, LA. Jim Tucker, Program Chair
📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

Oxidative DNA damage is a function of intracellular factors and the delivery mode of reactive oxygen species (ROS) into the cell. In the present study, hydrogen peroxide (H2O2) and nitric oxide (NO) were shown to induce cytotoxicity and mutation in the transgenic Chinese hamster G12 cells. Delivery